Following intramuscular trenbolone acetate powder administration of 100 mg of the maximum concentration (C max ) – 2.2 mg / l after 30 minutes. Communication with plasma proteins – no more than 40%. Quickly penetrates the liver and kidneys, slowly – in brain tissue (basic amount of drug accumulated in the pituitary gland). In humans, sulpiride only marginally subject to metabolism: 92% of the administered intramuscular dose is excreted in the urine in unchanged form by glomerular filtration.
as monotherapy or in combination with other psychotropic drugs:
- acute and chronic schizophrenia,
- acute delirious state,
- Depression different etiology.Contraindications
- Hypersensitivity to sulpiride another ingredient or drug,
- prolactin dependent tumors (such as prolactinomas and pituitary breast cancer)
- acute intoxication with alcohol, hypnotic drugs, narcotic analgesics,
- manic psychosis,
- affective disorders
- aggressive behavior,
- the period of breastfeeding,
- Children up to age 18 years.
Do not use this in conjunction with sultopride, agonists of dopaminergic receptors (amantadine, apomorphine, bromocriptine, cabergoline, entacapone, lisuride, pergolide, piribedil, pramipexole, kinagolid, ropinirole) except trenbolone acetate powder in patients with Parkinson’s disease.Precautions
To use caution in patients with epilepsy, hypertension, dysmenorrhea, severe heart disease, angina, renal and / or hepatic insufficiency, neuroleptic malignant syndrome, a history of glaucoma, prostatic hyperplasia, urinary retention in older age.
It is not recommended the appointment of sulpiride in combination with: levodopa, a drug capable of causing ventricular arrhythmias such as “torsade de pointes”: antiarrhythmics of class Ia (quinidine, gidrohinidin, disopyramide) and class III (amiodarone, sotalol, dofetilide, Ibutilide), some antipsychotics (tioridazein, chlorpromazine , Levomepromazine, trifluoperazine, tsiamemazin, amisulpride, tiaprid, pimozide, haloperidol, droperidol), and other drugs such as: bepridil, cisapride, difemanil, intravenous erythromycin, mizolastine, intravenous vincamine, halofantrine, pentamidine, sparfloxacin, moxifloxacin, etc.
Pregnancy and breast-feeding
Animal studies have not revealed teratogenic effects. A small number of women taking during pregnancy low dose sulpiride (approximately 200 mg / day) there was no teratogenic effect. With regard to the use of higher doses sulpiride data are not available. There trenbolone acetate powder is also no data on the potential effect of antipsychotic medications taken during pregnancy on the development of the fetal brain.
We do not recommend the appointment of sulpiride pregnant, except when the doctor to weigh the risks and benefits for the pregnant woman and the fetus, decides that the use of the drug necessary.
However, when using this drug during pregnancy is recommended whenever possible to limit the dose and duration of treatment. Neonates whose mothers received prolonged treatment with high doses of neuroleptics, rarely observed gastrointestinal symptoms (bloating, etc.) associated with atropine effect of certain drugs (especially in combination with antiparkinsonian agents), and extrapyramidal symptoms.
The drug is contraindicated lactation.