After 5 min after intravenous administration of 2 g sulbactam / cefoperazone (1 g sulbactam, 1 g cefoperazone) in serum are reached maximum concentrations of sulbactam and cefoperazone, averaging 130.2 and 236.8 mcg / ml, respectively.
Both of the drug components trenbolone acetate are well distributed in various tissues and body fluids, including the skin and soft tissues, the peritoneum, the bile, gallbladder wall, skin, appendix, fallopian tubes, ovaries, myometrium, and others. For sulbactam have a higher volume of distribution compared with that for cefoperazone .
Data on the presence of a pharmacokinetic interaction between sulbactam and cefoperazone appointed together there. With the introduction of the drug every 8-12 hours, significant changes in the pharmacokinetics of both cefoperazone / sulbactam were observed components; cumulative effect was not observed.
Sulbactam derived mainly kidneys – about 84% of the administered dose excreted in the urine within the first 8 hours.
Cefoperazone is derived mainly through the intestine (80%). Maximal concentrations in bile cefoperazone achieved between the first and third hours after administration and more than 100 times higher than serum. The rest of cefoperazone excreted by the kidneys (20-30% of the administered dose).
The trenbolone acetate sulbactam in adults with normal liver function and kidney averages about 1 hour, cefoperazone suffering. liver disease and / or obstruction of the biliary tract, the half-life of cefoperazone is usually lengthened; thus, renal excretion of the drug increases. Even with severe hepatic impairment in bile achieved therapeutic concentrations of cefoperazone, and the half-life is increased by only a factor of 2-4. There were no significant changes in the pharmacokinetics of cefoperazone in patients with renal impairment have been identified. A significant extension of the T ½sulbactam (from 6.9 to 9.7 hours) was found in patients with severe renal failure and terminal. Hemodialysis causes a significant change total clearance and volume of sulbactam distribution.
Both the drug component in small concentrations excreted in breast milk.
In elderly people with underlying age-related disorders of the kidneys and liver showed an increase in T ½ , a decrease in clearance and increase in the volume of distribution of both sulbactam, and cefoperazone.
The pharmacokinetics of sulbactam / cefoperazone in children is not significantly different compared to that of adults. T ½ sulbactam is from 0.91 to 1.42 hours, cefoperazone – from 1.44 to 1.88 hours.
Treatment of infections caused by susceptible microorganisms:
- infections of the upper and lower respiratory tract infections, including pneumonia, empyema pleura, lung abscess;
- bacterial meningitis;
- uncomplicated and complicated trenbolone acetate infections of the abdomen, including cholecystitis, cholangitis, peritonitis, abdominal abscess;
- infectious and inflammatory diseases of the pelvic organs (endometritis, salpingo, pelvioperitonit);
- Urinary tract infections (pyelitis, pyelonephritis);
- Skin and soft tissue infections caused by mixed aerobic-anaerobic flora;
- infections of bones and joints;